TENSILE PROPERTIES OF HUMAN KNEE-JOINT CARTILAGE .2. CORRELATIONS BETWEEN WEIGHT BEARING AND TISSUE PATHOLOGY AND THE KINETICS OF SWELLING

The nonequilibrium or kinetic swelling behavior of normal, fibrillated, and osteoarthritic (OA) (removed from total knee joint replacements) human knee joint cartilage has been measured using our isometric tensile apparatus (ITA). We found that large local variations exist in the manner with which human knee joint cartilage swells, including anisotropic effects, inhomogeneities, and dependence on local biochemical composition and pathological condition. The ITA provides three convenient biomechanical parameters - peak stress ( sigma //p), stress relaxation ( sigma //R), and diffusion coefficient (D) - to quantify the kinetics of swelling. The kinetic swelling behavior of cartilage should be used to provide important information not obtainable from equilibrium swelling studies.