HZI SYSTEMS FOR EEG PARAMETRIZATION AND CLASSIFICATION OF PSYCHOTROPIC-DRUGS

The EEG effects of 20 of the clinically most frequently used psychotropic drugs and 5 placebos were studied in 75 male volunteers in 5 simultaneously designed basic studies. In each of the 5 studies single oral dosages of 5 drugs (well known representatives of neuroleptics, antidepressants, anxiolytics and psychostimulants, as well as placebos) were investigated in 15 subjects in a double-blind latin-square research design using the methods of the Quantitative Pharmaco-EEG. The results demonstrated that the therapeutically equivalent effective compounds also have similar effects on human EEG. With a classification rule based on discriminant function 20, and with a classification rule based on correlation statistics, 19 of 25 compounds could be reclassified into correct clinical-therapeutic psychotropic drug groups. It is suggested that CEEG is an important tool in predicting and describing psychotropic properties of compounds, and should routinely be used in psychotropic drug development.