FLUORODENSITOMETRIC DETERMINATION OF BACLOFEN

被引：7

作者：

ERSOY, L

机构：

[1] Faculty of Pharmacy, University of Marmara, 80200 Nisantasi, Istanbul

来源：

ANALYST | 1990年 / 115卷 / 12期

关键词：

BACLOFEN DETERMINATION; BACLOFEN-4-CHLORO-7-NITROBENZOFURAZAN DERIVATIVE; FLUORODENSITOMETRIC DETERMINATION;

D O I：

10.1039/an9901501559

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A fluorodensitometric method was developed for the determination of baclofen. The method is based on the reaction of baclofen with 4-chloro-7-nitrobenzofurazan and measurement of the fluoresence intensity at 540 nm after chromatographic separation on a silica-gel plate. A linear relationship was found between relative fluorescence intensity and concentration over the range 4-100 ng of baclofen per spot. The detection and determination limits are 0.4 and 4.0 ng of baclofen per spot, respectively. The method was applied to human plasma. The recovery of baclofen from plasma was 96.67%.

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页码：1559 / 1560

页数：2

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