HEPATIC AND EXTRAHEPATIC DISPOSITION OF PROPOFOL IN PATIENTS UNDERGOING CORONARY-BYPASS SURGERY

被引：79

作者：

LANGE, H ^{[1
]}

STEPHAN, H ^{[1
]}

RIEKE, H ^{[1
]}

KELLERMANN, M ^{[1
]}

SONNTAG, H ^{[1
]}

BIRCHER, J ^{[1
]}

机构：

[1] UNIV GOTTINGEN,DEPT CLIN PHARMACOL,W-3400 GOTTINGEN,GERMANY

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1990年 / 64卷 / 05期

关键词：

Anaesthetics intravenous: propofol; Pharmacokinetics:; disposition; hepatic blood flow;

D O I：

10.1093/bja/64.5.563

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Summary: In order to clarify the relative contribution of the liver to the short term disposition of propofol, hepatic blood flow was measured during induction of anaesthesia with an i.v. bolus dose of propofol 2 mg kg-1. Total clearance of the drug was 2390 (SD 340) ml min-1, hepatic extraction 82% and hepatic clearance 1060 (260) ml min-1. During the 60-min period of observation, hepatic extraction of propofol increased from 79% to 92%. It is concluded that, within 1 h, only 44% of the administered dose is removed by the liver. Consequently, drug accumulation may occur with repeated dosing or infusion of propofol. The increase in extraction results presumably from slow release of propofol from the soy-bean emulsion. © 1990 Copyright: 1990 British Journal of Anaesthesia.

引用

页码：563 / 570

页数：8

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