CIPROFLOXACIN THERAPY OF EXPERIMENTAL ENDOCARDITIS CAUSED BY METHICILLIN-RESISTANT STAPHYLOCOCCUS-EPIDERMIDIS

被引：23

作者：

ROUSE, MS ^{[1
]}

WILCOX, RM ^{[1
]}

HENRY, NK ^{[1
]}

STECKELBERG, JM ^{[1
]}

WILSON, WR ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN,MAYO MED SCH,ROCHESTER,MN 55905

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 02期

关键词：

D O I：

10.1128/AAC.34.2.273

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ciprofloxacin or rifampin was significantly (P < 0.05) more effective than vancomycin or the combination of vancomycin plus gentamicin for the treatment of Staphylococcus epidermidis experimenal endocarditis. There were no significant differences in efficacy among any of the combinations of antimicrobial agents that included ciprofloxacin or rifampin. One animal treated with rifampin alone and one treated with the combination of vancomycin, rifampin, and gentamicin were found to be infected with rifampin-resistant strains of S. epidermidis during therapy. Resistant subpopulations of S. epidermidis were not detected during therapy with any other antimicrobial agent used alone or in combination. Ciprofloxacin alone or in combination with rifampin was effective therapy against. S. epidermidis experimental endocarditis.

引用

页码：273 / 276

页数：4

共 20 条

[1]

ARCHER GL, 1983, REV INFECT DIS S3, V5, P538

[2] INVITRO ACTIVITY OF CIPROFLOXACIN, NORFLOXACIN AND NALIDIXIC-ACID [J].