OPTICAL ISOMERS OF NAFTIDROFURYL (= 2-(DIETHYLAMINO)ETHYL 2-[(NAPHTH-1-YL)METHYL]-3-(TETRAHYDROFUR-2-YL)PROPANOATE)

被引：9

作者：

DESCOURS, D ^{[1
]}

FESTAL, D ^{[1
]}

LEGER, JM ^{[1
]}

CARPY, A ^{[1
]}

机构：

[1] UNIV BORDEAUX 2,FAC PHARM,CNRS,URA 605,F-33076 BORDEAUX,FRANCE

来源：

HELVETICA CHIMICA ACTA | 1991年 / 74卷 / 08期

关键词：

D O I：

10.1002/hlca.19910740818

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The four optical isomers of naftidrofuryl (1) were prepared in two ways, by separation and resolution of the two diastereoisomeric racemates and by synthesis from the enantiomers of tetrahydrofuran-2-methanol (6; see Scheme). The absolute configuration of one of the isomer as a tartrate monohydrate was established by X-ray crystallography thus allowing the deduction of the absolute configurations of the other three optimal isomers.

引用

页码：1757 / 1763

页数：7

共 13 条

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