THE RELATIONSHIP BETWEEN DRUG RELEASE RATE, PARTICLE-SIZE AND SWELLING OF SILICONE MATRICES

被引：40

作者：

GOLOMB, G

FISHER, P

RAHAMIM, E

机构：

[1] The Hebrew University of Jerusalem, Department of Pharmacy, School of Pharmacy, Jerusalem, 1120

[2] Electron Microscope Laboratory, The Hebrew University of Jerusalem

来源：

JOURNAL OF CONTROLLED RELEASE | 1990年 / 12卷 / 02期

关键词：

drug release rate; implantable systems; silicons matrices;

D O I：

10.1016/0168-3659(90)90088-B

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

Matrices composed of silicone elastomer (polydimethylsiloxane) have been used extensively as implantable controlled release drug delivery systems. This study examined the relationship between drug particle size, release rate and swelling of silastic matrices, by using a model drug (potassium dichromate) and two types of silicone polymer. The drug particles were found to be the driving force for water uptake by the matrix. The release rate was directly proportional to the degree of swelling, which in turn was directly proportional to the drug particle size. The release rate and swelling of matrices composed of silastic 382 increased with decreasing drug particle size, while increasing drug particle size resulted in increased release rate and decreased swelling of silastic Q7 matrices, probably because air is entrapped during fabrication of these matrices. More retarded release and swelling was exhibited by silastic Q7 matrices in comparison to matrices composed of silastic 382, probably due to the different physical properties of these silicones. © 1990.

引用

页码：121 / 132

页数：12

共 18 条

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