ARE SEVERAL G-PROTEINS INVOLVED IN THE DIFFERENT EFFECTS OF ENDOTHELIN-1 IN MOUSE STRIATAL ASTROCYTES

被引：76

作者：

MARIN, P

DELUMEAU, JC

DURIEUTRAUTMANN, O

LENGUYEN, D

PREMONT, J

STROSBERG, AD

COURAUD, PO

机构：

[1] INST COCHIN GENET MOLEC,IMMUNOPHARMACOL MOLEC LAB,22 RUE MECHAIN,F-75014 PARIS,FRANCE

[2] CTR PHARMACOL ENDOCRINOL,CNRS,INSERM,MONTPELLIER,FRANCE

[3] COLL FRANCE,CHAIR NEUROPHARMACOL,INSERM,U114,F-75231 PARIS 05,FRANCE

来源：

JOURNAL OF NEUROCHEMISTRY | 1991年 / 56卷 / 04期

关键词：

ENDOTHELIN; RECEPTOR; TRANSDUCTION PATHWAYS;

D O I：

10.1111/j.1471-4159.1991.tb11421.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

High-affinity specific receptors of endothelin (ET-1) were identified on primary cultures of mouse embryo striatal astrocytes by binding experiments performed with I-125-ET-1. Stimulation of production of inositol phosphates, a biphasic increase of the intracellular calcium concentration, and inhibition of cyclic AMP accumulation were observed in the same cells under ET-1 stimulation. Pretreatment of these cells with Bordetella pertussis toxin affected these effects to different extends, an observation suggesting that they are mediated by multiple transduction pathways, possibly involving several guanine nucleotide-binding proteins.

引用

页码：1270 / 1275

页数：6

共 28 条

[1] Y1 RECEPTORS FOR NEUROPEPTIDE-Y ARE COUPLED TO MOBILIZATION OF INTRACELLULAR CALCIUM AND INHIBITION OF ADENYLATE-CYCLASE [J].