A THERMODYNAMIC APPRAISAL OF THE RADICAL SINK HYPOTHESIS

被引：52

作者：

KOPPENOL, WH

机构：

[1] LOUISIANA STATE UNIV,DEPT CHEM,BATON ROUGE,LA 70803

[2] LOUISIANA STATE UNIV,DEPT BIOCHEM,BATON ROUGE,LA 70803

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1993年 / 14卷 / 01期

关键词：

SUPEROXIDE FORMATION IN CELL; GLUTATHIONE RADICAL SCAVENGER; SUPEROXIDE DISMUTASE; ANTIOXIDANT DEFENSE; THERMODYNAMICS; REDUCTION POTENTIALS; FREE RADICALS;

D O I：

10.1016/0891-5849(93)90513-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analysis of the radical sink hypothesis (C. C. Winterbourn, preceding paper) shows that all reactions are energetically feasible. The process is made irreversible by the formation of superoxide from the GSSG.- anion, which is an extremely favourable reaction, -31 kcal/mol. The overall process has a Gibbs energy change of approximately -50 kcal/mol, depending on the radical that is being ''repaired'' by glutathione.

引用

页码：91 / 94

页数：4

共 20 条

[1] ARMSTRONG DA, 1990, SULFUR CTR REACTIVE, P121
[2] ASMUS KD, 1990, METHOD ENZYMOL, V186, P168
[3] HO2 ELIMINATION FROM ALPHA-HYDROXYALKYLPEROXYL RADICALS IN AQUEOUS-SOLUTION
BOTHE, E
SCHUCHMANN, MN
SCHULTEFROHLINDE, D
VONSONNTAG, C
[J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1978, 28 (4-5) : 639 - 644
[4] THIYL FREE-RADICALS - DIRECT OBSERVATIONS OF ELECTRON-TRANSFER REACTIONS WITH PHENOTHIAZINES AND ASCORBATE
FORNI, LG
MONIG, J
MORAARELLANO, VO
WILLSON, RL
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1983, (07): : 961 - 965
[5] JONES DP, 1988, OXIDASES RELATED RED, P127
[6] REACTIONS INVOLVING SINGLET OXYGEN AND SUPEROXIDE ANION
KOPPENOL, WH
[J]. NATURE, 1976, 262 (5567) : 420 - 421
[7] KOPPENOL WH, 1989, SCIENCE, V246, P311
[8] REDUCTION POTENTIAL OF THE CO2/CO2.- COUPLE - A COMPARISON WITH OTHER C1 RADICALS
KOPPENOL, WH
RUSH, JD
[J]. JOURNAL OF PHYSICAL CHEMISTRY, 1987, 91 (16) : 4429 - 4430
[9] OXYRADICAL REACTIONS - FROM BOND-DISSOCIATION ENERGIES TO REDUCTION POTENTIALS
KOPPENOL, WH
[J]. FEBS LETTERS, 1990, 264 (02) : 165 - 167
[10] ON THE REACTION OF MOLECULAR-OXYGEN WITH THIYL RADICALS - A REEXAMINATION
MONIG, J
ASMUS, KD
FORNI, LG
WILLSON, RL
[J]. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1987, 52 (04) : 589 - 602

← 1 2 →