INVITRO CYTOTOXICITY OF METHYLATED PHENYLENEDIAMINES

被引：4

作者：

BABICH, H

STERN, A

MUNDAY, R

机构：

[1] NYU,SCH MED,DEPT PHARMACOL,NEW YORK,NY 10003

[2] MINIST AGR & FISHERIES,RUAKURA AGR CTR,HAMILTON,NEW ZEALAND

来源：

TOXICOLOGY LETTERS | 1992年 / 63卷 / 02期

关键词：

NEUTRAL RED CYTOTOXICITY ASSAY; PHENYLENEDIAMINES; MUSCLE NECROSIS; WURSTER SALTS; REACTIVE OXYGEN SPECIES;

D O I：

10.1016/0378-4274(92)90009-9

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The acute cytotoxicities of methylated phenylenediamines (PDs) were evaluated with the neutral red assay, using BALB/c 3T3 mouse fibroblasts as the bioindicators. When the test agents were grouped according to their degree of methylation, good correlations were noted between their in vitro cytotoxicity and their in vivo myotoxicity to experimental animals, as well as to their in vitro autoxidation rates. For test agents of comparable methylation, the sequence of potency was ring-methylated p-PD > N-methylated p-PD >> N-methylated o-PD > N-methylated m-PD.

引用

页码：171 / 179

页数：9

共 15 条

[1]

[Anonymous], 1978, IARC MONOGRAPHS EVAL, V16

[2] STRUCTURE ACTIVITY RELATIONSHIP (SAR) MODELS ESTABLISHED INVITRO WITH THE NEUTRAL RED CYTOTOXICITY ASSAY [J].