THE DRUG-DRUG INTERACTION EFFECTS OF HALOPERIDOL ON PLASMA CARBAMAZEPINE LEVELS

被引：25

作者：

IWAHASHI, K

MIYATAKE, R

SUWAKI, H

HOSOKAWA, K

ICHIKAWA, Y

机构：

[1] KAGAWA MED SCH,DEPT BIOCHEM,MIKI,KAGAWA 76101,JAPAN

[2] UNIV HOSP MIKI,DEPT NEUROPSYCHIAT,MIKI,KAGAWA,JAPAN

来源：

CLINICAL NEUROPHARMACOLOGY | 1995年 / 18卷 / 03期

关键词：

D O I：

10.1097/00002826-199506000-00003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The metabolic interaction between carbamazepine (CBZ) and haloperidol (HP) was studied in Japanese schizophrenic patients treated with HP but not with CBZ and with both CBZ and HP. The serum CBZ concentrations in patients treated without KP were significantly decreased (p < 0.05), on average similar to 40%, as compared to those in patients treated with both CBZ and HP, whereas the serum HP concentrations in patients treated with both HP and CBZ were significantly decreased (p < 0.05), as compared to those in patients treated with HP but not with CBZ. The effect of HP, which prevents the serum CBZ level from decreasing, was shown in this study.

引用

页码：233 / 236

页数：4

共 12 条

[1] AUTO-INDUCTION OF CARBAMAZEPINE METABOLISM IN CHILDREN EXAMINED BY A STABLE ISOTOPE TECHNIQUE [J].