REDUCED CAMP-DEPENDENT PHOSPHORYLATION IN STRIATUM AND NUCLEUS ACCUMBENS OF AGED RATS - EVIDENCE OF AN ALTERED FUNCTIONING OF D1 DOPAMINOCEPTIVE NEURONS

被引：13

作者：

GOVONI, S

RIUS, RA

BATTAINI, F

TRABUCCHI, M

机构：

[1] UNIV MILAN, INST PHARMACOL SCI, VIA ANDREA SARTO 21, I-20129 MILAN, ITALY

[2] UNIV ROME, I-00100 ROME, ITALY

来源：

JOURNALS OF GERONTOLOGY | 1988年 / 43卷 / 04期

关键词：

D O I：

10.1093/geronj/43.4.B93

中图分类号：

R4 [临床医学]; R592 [老年病学];

学科分类号：

1002 ; 100203 ; 100602 ;

摘要：

Cyclic AMP-dependent phosphorylation was measured in particulate and in cytosolic fractions of two brain dopaminergic areas, i.e., striatum and nucleus accumbens, of young (3 months) and old (24 months) rats. A reduced cAMP-stimulated 32P incorporation was observed in several protein bands in both brain areas in the aged group. In the soluble fraction the reduced phosphorylation of DARPP-32, which is specific for dopaminoceptive neurons bearing D-1 receptors, may be of particular relevance in the mechanisms of age-related changes in dopaminergic transmission.

引用

页码：B93 / B97

页数：5

共 33 条

[1]

BREESE GR, 1985, J PHARMACOL EXP THER, V234, P447

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