RESHAPING HUMAN-ANTIBODIES FOR THERAPY

被引:1133
作者
RIECHMANN, L
CLARK, M
WALDMANN, H
WINTER, G
机构
[1] MRC,MOLEC BIOL LAB,HILLS RD,CAMBRIDGE CB2 2QH,ENGLAND
[2] UNIV CAMBRIDGE,DEPT PATHOL,CAMBRIDGE CB2 1QP,ENGLAND
关键词
D O I
10.1038/332323a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:323 / 327
页数:5
相关论文
共 46 条
  • [1] TOLERANCE TO RAT MONOCLONAL-ANTIBODIES - IMPLICATIONS FOR SEROTHERAPY
    BENJAMIN, RJ
    COBBOLD, SP
    CLARK, MR
    WALDMANN, H
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 163 (06) : 1539 - 1552
  • [2] PRODUCTION OF FUNCTIONAL CHIMAERIC MOUSE HUMAN-ANTIBODY
    BOULIANNE, GL
    HOZUMI, N
    SHULMAN, MJ
    [J]. NATURE, 1984, 312 (5995) : 643 - 646
  • [3] IMMUNOGLOBULIN HEAVY-CHAIN LOCUS OF THE RAT - STRIKING HOMOLOGY TO MOUSE ANTIBODY GENES
    BRUGGEMANN, M
    FREE, J
    DIAMOND, A
    HOWARD, J
    COBBOLD, S
    WALDMANN, H
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (16) : 6075 - 6079
  • [4] COMPARISON OF THE EFFECTOR FUNCTIONS OF HUMAN-IMMUNOGLOBULINS USING A MATCHED SET OF CHIMERIC ANTIBODIES
    BRUGGEMANN, M
    WILLIAMS, GT
    BINDON, CI
    CLARK, MR
    WALKER, MR
    JEFFERIS, R
    WALDMANN, H
    NEUBERGER, MS
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 166 (05) : 1351 - 1361
  • [5] Carson D A, 1986, Adv Immunol, V38, P275, DOI 10.1016/S0065-2776(08)60009-7
  • [6] CANONICAL STRUCTURES FOR THE HYPERVARIABLE REGIONS OF IMMUNOGLOBULINS
    CHOTHIA, C
    LESK, AM
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1987, 196 (04) : 901 - 917
  • [7] DOMAIN ASSOCIATION IN IMMUNOGLOBULIN MOLECULES - THE PACKING OF VARIABLE DOMAINS
    CHOTHIA, C
    NOVOTNY, J
    BRUCCOLERI, R
    KARPLUS, M
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1985, 186 (03) : 651 - 663
  • [8] CLARK MR, 1987, J NATL CANCER I, V79, P1393
  • [9] DELAND FH, 1982, RADIONUCLIDE IMAGING, P289
  • [10] EHRLICH P, 1957, IMMUNOLOGY CANCER RE, V2