Recombinant Human Transforming Growth Factor-Beta 1 (rhTGF-beta 1) Enhances Healing and Strength of Granulation Skin Wounds

被引：40

作者：

Beck, L. Steven ^{[1
]}

Chen, Theresa L. ^{[1
]}

Mikalauski, Philip ^{[2
]}

Ammann, Arthur J.

机构：

[1] Genentech Inc, Res & Dev, 460 Point San Bruno Blvd, San Francisco, CA 94080 USA

[2] Utah Biomed Test Lab Inc, Salt Lake City, UT 84108 USA

来源：

GROWTH FACTORS | 1990年 / 3卷 / 04期

关键词：

recombinant human transforming growth factor beta 1; granulation wounds; tensile strength; blood flow;

D O I：

10.3109/08977199009003669

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

A new animal model to study secondary intention wound healing and the effects of topically applied rhTGF-beta 1 was developed. A time course study was performed of full thickness 6 mm punch wounds placed on the backs of anesthetized pigs and treated once with either 3% methylcellulose or rhTGF-beta 1 in 3% methylcellulose or left untreated. Wounds receiving rhTGF-beta 1 had enhanced tensile strength at days 4 and 7 compared to controls. Studies of the response on days 4 and 7 to graded doses of rhTGF-beta 1 showed that a dose of 250 or 2500 ng rhTGF-beta 1 gave a similar enhanced wound strength, while 25 ng rhTGF-beta 1 had no effect. Blood flow to treated granulating wounds as measured by Ce-141 microspherrs indicate an increase in flow in wounds treated with 250, 500 or 2500ng rhTGF-beta 1 compared to controls. These results indicate a possible use for rhTGF-beta 1 in enhancing wound healing clinically.

引用

页码：267 / 275

页数：9

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