REGENERATION OF VITAMIN-A DEFICIENT RAT TRACHEAL EPITHELIUM AFTER MILD MECHANICAL INJURY - GROWTH-KINETICS AND CELLULAR-DIFFERENTIATION

被引：20

作者：

LANE, BP

GORDON, RE

机构：

[1] Department of Pathology, State University of New York, New York, New York, Stony Brook, Long Island

来源：

DIFFERENTIATION | 1979年 / 14卷 / 1-2期

关键词：

D O I：

10.1111/j.1432-0436.1979.tb01015.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mild mechanical abrasion of tracheal epithelium of Vitamin A deficient rats removed the superficial cells and spared basal cells which divided to repopulate the damaged area. The proliferative cells passed through a period of DNA synthesis with the greatest numbers of thymidine incorporating cells in samples labelled 22 h after injury. A peak of cell division occurred at 32 h and there was no further DNA synthesis or cell division. The area of wounding exhibited squamous metaplasia while normal pseudostratified muco-ciliary structure was retained by adjacent epithelium which had not been injured. The data indicates that squamous metaplasia in the respiratory epithelium in longstanding Vitamin A deficiency is due to redirected differentiation of basal cells and is seen only after mitotic activity has occurred. © 1979, International Society of Differentiation. All rights reserved.

引用

页码：87 / 93

页数：7

共 17 条

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