LIQUID-CHROMATOGRAPHIC INVESTIGATION OF QUINOXALINE ANTIBIOTICS AND THEIR ANALOGS BY MEANS OF ULTRAVIOLET DIODE-ARRAY DETECTION

被引:13
作者
ALFREDSON, TV
MAKI, AH
ADASKAVEG, ME
EXCOFFIER, JL
WARING, MJ
机构
[1] VARIAN INSTRUMENT GRP,WALNUT CREEK,CA 94598
[2] UNIV CAMBRIDGE,DEPT PHARMACOL,CAMBRIDGE CB2 2QD,ENGLAND
来源
JOURNAL OF CHROMATOGRAPHY | 1990年 / 507卷
关键词
D O I
10.1016/S0021-9673(01)84205-9
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Numerical formats for evaluation of spectral purity and for spectral comparison of ultraviolet diode-array detector data, together with library search routines, were applied to the liquid chromatographic analysis of echinomycin, triostin A and their systhetic and biosynthetic analogues. Samples of monoquinoline and bisquinoline analogues of echinomycin were found to contain echinomycin and the other respective analogue. Triostin A and its undermethylated systhetic analogues, des-N-tetramethyltriostin A (TANDEM) and [MeCys3,MeCys7]-TANDEM, were each composed of two or more components. Triostin A primarily consisted of a major chromatographic component and a minor component with very similar ultraviolet spectral features. TANDEM exhibited three chromatographic components with nearly identical ultraviolet spectral characteristics. Apparent conformational interconversion of at least two forms of the [MeCys3,MeCys7]-TANDEM analogue was observed by reversed-phase liquid chromatography. An activation energy of 15 kcal/mol was estimated for the interconversion based upon an Arrhenius plot of the data. © 1990.
引用
收藏
页码:277 / 292
页数:16
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