UNUSUAL CYTOGENETICS IN A CASE OF ACUTE LYMPHOBLASTIC-LEUKEMIA

被引：5

作者：

MORSE, HG

HAYS, T

ODOM, LF

机构：

[1] Department of Biochemistry, Biophysics and Genetics, University of Colorado Health Sciences Center

[2] Department of Oncology/Hematology, Children's Hospital, Denver

来源：

MEDICAL AND PEDIATRIC ONCOLOGY | 1979年 / 7卷 / 03期

关键词：

acute lymphoblastic leukemia; cytogenetic study;

D O I：

10.1002/mpo.2950070311

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The cytogenetics in the study of a patient with acute lymphoblastic leukemia are presented. Initially, a large proportion of both unstimulated and phytohemagglutinin (PHA)‐stimulated blood mitoses showed an abnormal karyo‐type with a 7;12 translocation and a trisomy 19. At the time of relapse, a PHA‐stimulated culture showed the clonal abnormality as well as dicentric chromosomes in normal cells, the latter possibly resulting from treatment. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：257 / 262

页数：6

共 9 条

[1]

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[2]

Morse HG, Humbert JR, Hutter JJ, Robinson A, Karyotyping of bone marrow cells in hematologic diseases, Hum Genet, 37, pp. 33-39, (1977)

[3]

Lloyd DC, Dolphin GW, Radiation‐induced chromosome damage in human lymphocytes, Br J Ind Med, 34, pp. 261-273, (1977)

[4]

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[5]

Morse HG, Ducore JM, Hays T, Peakman D, Robinson A, Multiple leukemic clones in acute leukemia of childhood, Hum Genet, 40, pp. 269-278, (1978)

[6]

Walker LMS, Hardy JD, Philadelphia chromosome in PHA stimulated lymphocytes in acute leukemia, Lancet, 2, pp. 1301-1302, (1975)

[7]

Ling NR, Kay JE, DNA synthesis and the cell cycle, Lymphocyte Stimulation, (1975)

[8]

Morse HG, Hays T, Peakman D, Rose B, Robinson A, Acute nonlymphoblastic leukemia in childhood: High incidence of clonal abnormalities and non‐random changes, Cancer, 44, pp. 164-170, (1979)

[9]

Hays T, Morse H, Peakman D, Rose B, Robinson A, Cytogenetic studies of chronic myelocytic leukemia in children and adolescents, Cancer, 44, pp. 210-214, (1979)

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