PROTEIN-BINDING OF VANCOMYCIN IN A PATIENT WITH IMMUNOGLOBULIN-A MYELOMA

被引：21

作者：

CANTU, TG

DICK, JD

ELLIOTT, DE

HUMPHREY, RL

KORNHAUSER, DM

机构：

[1] JOHNS HOPKINS UNIV,DEPT ONCOL,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,DEPT PATHOL,BALTIMORE,MD 21205

[3] JOHNS HOPKINS UNIV,DEPT MED,BALTIMORE,MD 21205

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 07期

关键词：

D O I：

10.1128/AAC.34.7.1459

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Atypical vancomycin pharmacokinetics were observed in an immunoglobulin A myeloma patient. Drug concentrations in serum were extremely elevated, the elimination half-life was prolonged despite normal renal function, and the vancomycin therapy was ineffective. Extensive binding of vancomycin, presumably by high concentrations of an aberrant immunoglobulin A protein, may have accounted for these observations.

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页码：1459 / 1461

页数：3

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