COMPLEMENT ACTIVATION BEFORE, DURING AND AFTER CARDIOPULMONARY BYPASS

被引：31

作者：

BONSER, RS

DAVE, JR

JOHN, L

GADEMSETTY, MK

CARTER, PG

DAVIES, E

TAYLOR, P

GAYA, H

LENNOX, SC

VERGANI, D

机构：

[1] Department of Surgery, Brompton Hospital, London

[2] Department of Anaesthesia, Brompton Hospital, London

[3] Department of Microbiology, Brompton Hospital, London

[4] Department of Immunology, Kings College Hospital, London

来源：

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY | 1990年 / 4卷 / 06期

关键词：

Bubble oxygenation; Cardiopulmonary bypass; Complement activation; Extracorporeal circulation;

D O I：

10.1016/1010-7940(90)90204-D

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Plasma levels of the complement parent molecules C3, C4, and factor B and their split products, C3d, C4d, and Ba were measured in 12 patients undergoing cardiopulmonary bypass for coronary artery surgery. Alternative and common complement pathway activation, demonstrated by statisticallysignificant rising levels of Ba (P < 0.05), and C3d (P < 0.05) and by elevated Ba:B (P < 0.05) and C3d:C3 (P < 0.05)ratios were found before the institution of cardiopulmonary bypass but following heparin administration suggesting that heparin may itself initiate alternative pathway activation. In addition, significant depletion of parent complement components and elevation of split product concentrations was seen during bypass suggesting classical and alternatepathway activation (P < 0.01). This study clarifies the pathways of complement activation during bypass and presents evidence that heparin administration may initially activate the complement cascade. © Springer-Verlag.

引用

页码：291 / 296

页数：6

共 30 条

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