TRANSITION-METAL PROMOTED ALKYLATIONS OF UNSATURATED ALCOHOLS - ALKYLATION OF ALKYNOLS WITH ORGANO-ALANES PROMOTED BY GROUP-4A METAL-CYCLOPENTADIENYL COMPOUNDS

被引：25

作者：

BROWN, DC ^{[1
]}

NICHOLS, SA ^{[1
]}

GILPIN, AB ^{[1
]}

THOMPSON, DW ^{[1
]}

机构：

[1] COLL WILLIAM & MARY,DEPT CHEM,WILLIAMSBURG,VA 23185

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 20期

关键词：

D O I：

10.1021/jo01334a002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Studies on the carbometalation of several alkynols, using bis(cyclopentadienyl)- and bis(methylcyclo-pentadienyl)titanium dichloride-organoalane systems, are reported. Alkynols of three types were examined: (1) HO(CH2)nC≡CH, n = 2, 3, 4; (2) HOCHRCH2C≡CH, R ≡ CH3, C2H5; and (3) HOCH2CH2C≡CR, R ≡ CH3, C2H5. Additionally, 3-butyn-l-ol was examined with bis(cyclopentadienyl)zirconium dichloride-organoalanes. Finally, the carbometalation of the trimethylsilyl ether of 3-butyn-l-ol was studied with bis(cyclopentadie-nyl)titanium dichloride-diethylaluminum chloride. All substrates react to produce substituted olefinic alcohols. © 1979, American Chemical Society. All rights reserved.

引用

页码：3457 / 3461

页数：5

共 29 条

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