PHYSIOLOGICAL, BIOCHEMICAL, AND MATHEMATICAL STUDIES OF MICRO-AEROBIC CONTINUOUS ETHANOL FERMENTATION BY SACCHAROMYCES-CEREVISIAE .3. MATHEMATICAL-MODEL OF CELLULAR ENERGETICS AND CATABOLISM

被引:12
作者
GROSZ, R [1 ]
STEPHANOPOULOS, G [1 ]
机构
[1] MIT,DEPT CHEM ENGN,CAMBRIDGE,MA 02139
关键词
D O I
10.1002/bit.260361008
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Mathematical models of the catabolic pathways, the utilization and waste of ATP, and the factors affecting yeast growth in a micro‐aerobic chemostat are presented. The models incorporate the intracellular metabolite and enzyme activity assays performed in Part II to explain the unusual macroscopic chemostat behaviors reported in Part I. The catabolic model successfully predicts a maximum in the specific ethanol productivity as a function of the intracellular ATP concentration. The ATP balance model enables the prediction of the intracellular ATP concentration and the ATP yield for given dissolved oxygen concentrations. Finally, in the context of a growth model, singularity theory provides a framework to explain the transition observed in Part I between hysteresis and the monotonic biomass versus oxygenation profiles in response to changes in the nutrient composition. The models serve to organize data and to concretely express proposed metabolic mechanisms and cause–effect hypotheses. The model is only applicable to the micro‐aerobic and excess glucose conditions encountered in this study. Copyright © 1990 John Wiley & Sons, Inc.
引用
收藏
页码:1030 / 1040
页数:11
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