GUINEA-PIG VERY LOW-DENSITY LIPOPROTEINS ARE A GOOD SUBSTRATE FOR LIPOPROTEIN-LIPASE

被引：16

作者：

WALLINDER, L ^{[1
]}

BENGTSSON, G ^{[1
]}

OLIVECRONA, T ^{[1
]}

机构：

[1] UNIV UMEA,DEPT CHEM,PHYSIOL CHEM SECT,S-90187 UMEA,SWEDEN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 575卷 / 03期

关键词：

(Guinea pig); Apolipoprotein CII; Lipoprotein lipase; VLDL;

D O I：

10.1016/0005-2760(79)90115-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In contrast to plasma from most other animals, guinea pig plasma causes little or no stimulation of lipoprotein lipase activity. Very low density lipoproteins (VLDL) isolated by ultracentrifugation of guinea pig serum caused a definite stimulation of lipase activity, whereas the infranatant inhibited the activity. Gel filtration in 5 M guanidinium hydrochloride of delipidated VLDL demonstrated that the activation was caused by a low molecular weight protein. The VLDL themselves were hydro lized at similar rates as human VLDL both by guinea pig and by bovine lipoprotein lipases. Thus, guinea pig VLDL contain an activator for lipoprotein lipase analogous to that in other animals and there is enough of the activator to support rapid hydrolysis of the VLDL lipids by the lipase. © 1979.

引用

页码：458 / 462

页数：5

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