A NOTE ON EFFICIENT ESTIMATION OF MUTATION-RATES USING LURIA-DELBRUCK FLUCTUATION ANALYSIS

被引：15

作者：

KOZIOL, JA

机构：

[1] Department of Molecular and Experimental Medicine, Scripps Clinic, Research Foundation, La Jolla, CA 92037

来源：

MUTATION RESEARCH | 1991年 / 249卷 / 01期

关键词：

LURIA-DELBRUCK FLUCTUATION ANALYSIS; MUTATION RATES; ESTIMATION;

D O I：

10.1016/0027-5107(91)90154-G

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The maximum likelihood and Luria-Delbruck P0 methods for the estimation of spontaneous mutation rates are compared. The maximum likelihood method is fully efficient, utilizing all available information in a fluctuation experiment, but can be numerically cumbersome. Under certain conditions, there is little loss of efficiency using the P0 method, which is readily implemented numerically. Design considerations should aid investigators in minimizing statistical errors associated with the statistical analysis of fluctuation experiments.

引用

页码：275 / 280

页数：6

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