A SILICON MICROMACHINED DEVICE FOR USE IN BLOOD-CELL DEFORMABILITY STUDIES

被引：34

作者：

TRACEY, MC ^{[1
]}

GREENAWAY, RS ^{[1
]}

DAS, A ^{[1
]}

KAYE, PH ^{[1
]}

BARNES, AJ ^{[1
]}

机构：

[1] BARNET GEN HOSP,BARNET EN5 3DJ,HERTS,ENGLAND

来源：

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 1995年 / 42卷 / 08期

基金：

英国惠康基金;

关键词：

D O I：

10.1109/10.398635

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

An application of silicon micromachining to the analysis of blood cell theology is described. The system, based upon a micromachined flow cell, provides a specific measurement of each cell in a statistically significant population in terms of both flow velocity profile and an index of cell volume while the cells flow through an array of microchannels. The-rationale, design, and fabrication of the silicon micromachined flow cell is discussed. Interrelated considerations determining the design of the associated fluidic, mechanical, imaging, and real-time image analysis subsystems are examined. Sample data comparing normal and iron deficiency anaemic blood are presented to illustrate the potential of this technique.

引用

页码：751 / 761

页数：11

共 34 条

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