INTERLEUKIN-8 (IL-8) IN SYNOVIAL-FLUID OF RHEUMATOID AND NONRHEUMATOID JOINT EFFUSIONS

被引：34

作者：

VERBURGH, CA ^{[1
]}

HART, MHL ^{[1
]}

AARDEN, LA ^{[1
]}

SWAAK, AJG ^{[1
]}

机构：

[1] ZUIDERZIEKENHUIS,DEPT INTERNAL MED,ROTTERDAM,NETHERLANDS

来源：

CLINICAL RHEUMATOLOGY | 1993年 / 12卷 / 04期

关键词：

INTERLEUKIN-8; IL-8; SYNOVIAL FLUID;

D O I：

10.1007/BF02231778

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

IL-8 was measured in knee joint synovial fluid of 60 patients with rheumatoid arthritis, 8 with gout, 6 with osteoarthritis and 4 with meniscus lesions. IL-8 could be demonstrated in most SF samples. The highest levels were observed in rheumatoid joint effusions, yet mean levels were not significantly different between the different subgroups (mean +/- SE; RA 1537 +/- 3049 pg/ml, gout 570 +/- 952 pg/ml, OA/ML 178 +/- 188 pg/ml). In RA patients, IL-8 levels could not be related to various serological, clinical or radiological parameters. However, a correlation was observed between SF levels of IL-8 with those of lactate, LDH, beta 2-microglobulin and glucose. These observations suggest that next to the laboratory parameters IL-8 will be a parameter of the activity of the local inflammatory process. The results also demonstrate that IL-8 is not a disease-specific marker of joint inflammation.

引用

页码：494 / 499

页数：6

共 37 条

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