IMMUNIZATION OF DAHL SS/JR RATS WITH AN OUABAIN CONJUGATE MITIGATES HYPERTENSION

被引：26

作者：

GOMEZSANCHEZ, EP

GOMEZSANCHEZ, CE

FORT, C

机构：

[1] Research Service and Department of Internal Medicine, James A. Haley Veterans Hospital, University of South Florida Health Science Center, Tampa, FL

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1994年 / 7卷 / 07期

关键词：

HYPERTENSION; OUABAIN; DAHL SALT-SENSITIVE RAT; CARDIAC GLYCOSIDE;

D O I：

10.1093/ajh/7.7.591

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Inhibition of the Na+/K+-ATPase by a circulating endogenous digitalis- or ouabain-like substance has been associated with the pathogenesis of several forms of clinical and experimental hypertension. Inbred salt-sensitive Dahl SS/jr rats were immunized with either urease or a ouabain-urease conjugate, then challenged with a high salt diet. The salt-induced increase in blood pressure in the ouabain-urease-immunized animals was significantly less than that of the urease-inoculated rats. Sera of the ouabain-urease immunized animals cross-reacted with ouabagenin, digoxigenin, digoxin, and digitoxin, but not with aldosterone, corticosterone, deoxycorticosterone (DOC), 18-hydroxy DOC, or 19-nor DOC. The fact that hypertension was not completely blocked by immunization supports ample evidence that the disease in these animals is multifactorial with several genes involved.

引用

页码：591 / 596

页数：6

共 54 条

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