GLC ASSAY FOR BENDROFLUMETHIAZIDE - PRELIMINARY DATA ABOUT ITS PLASMA-LEVEL IN MAN

被引：22

作者：

BEERMANN, B

GROSCHINSKYGRIND, M

LINDSTROM, B

机构：

[1] NATL BOARD HLTH & WELF, DEPT DRUGS, DIV CLIN DRUG TRIALS, STOCKHOLM, SWEDEN

[2] SERAFIMERLASARETTET, DEPT MED, S-11283 STOCKHOLM, SWEDEN

[3] SERAFIMERLASARETTET, CLIN MICROBIOL LAB, S-11283 STOCKHOLM, SWEDEN

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1976年 / 10卷 / 3-4期

关键词：

D O I：

10.1007/BF00558343

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A GLC method for determination of bendroflumethiazide was developed, using extractive methylation. Cyclopenthiazide was used as internal standard. The maximal plasma concentration (56-107 ng/ml) after bendroflumethiazide 10 mg given orally to 4 healthy volunteers was seen at 2-2.5 h. On the slope between 4 and 10 h t 1/2 [half life] averaged 2.7 h.

引用

页码：293 / 295

页数：3

共 4 条

[1] S35-LABELED BENDROFLUMETHIAZIDE IN HUMAN BEINGS - CLINICAL STUDIES [J].