BINDING OF HEPARIN ON SURFACE OF CULTURED HUMAN ENDOTHELIAL CELLS

被引：254

作者：

GLIMELIUS, B ^{[1
]}

BUSCH, C ^{[1
]}

HOOK, M ^{[1
]}

机构：

[1] ROYAL VET COLL,DEPT MED CHEM,UPPSALA,SWEDEN

来源：

THROMBOSIS RESEARCH | 1978年 / 12卷 / 05期

关键词：

D O I：

10.1016/0049-3848(78)90271-2

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

3H-labelled heparin was shown to bind to the surface of cultured human endothelial cells. The binding was time dependent, saturable, reversible and trypsin sensitive. The binding capacity corresponds to about 106 molecules of heparin per cell. Labelled material released from the cells retained its ability to bind to antithrombin III. Binding of heparin to endothelial cells as well as its release is suggested to be of importance in the pharmacokinetics of heparin and to influence the non-thrombogenic properties of the endothelial lining during heparin therapy. © 1978.

引用

页码：773 / 782

页数：10

共 19 条

[1]

INTERACTION OF HEPARIN WITH PROTEINS - DEMONSTRATION OF DIFFERENT BINDING-SITES FOR ANTITHROMBIN AND LIPOPROTEIN-LIPASE [J].