IMMUNOMODULATORY EFFECT OF PERIPHERAL BENZODIAZEPINE RECEPTOR LIGANDS ON HUMAN MONONUCLEAR-CELLS

被引：54

作者：

BESSLER, H

WEIZMAN, R

GAVISH, M

NOTTI, I

DJALDETTI, M

机构：

[1] GOLDA MED CTR,HASHARON HOSP,DEPT MED B,POB 121,IL-49372 PETAH TIQWA,ISRAEL

[2] GOLDA MED CTR,HASHARON HOSP,HEMATOL RES LAB,PETAH TIQWA,ISRAEL

[3] HASHARON HOSP,PETAH TIQWA,ISRAEL

[4] TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL

[5] TECHNION ISRAEL INST TECHNOL,FAC MED,DEPT PHARMACOL,HAIFA,ISRAEL

[6] TECHNION ISRAEL INST TECHNOL,RAPPAPORT FAMILY INST RES MED SCI,HAIFA,ISRAEL

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1992年 / 38卷 / 1-2期

关键词：

PERIPHERAL BENZODIAZEPINE RECEPTOR; MITOGEN-INDUCED PROLIFERATION; INTERLEUKIN-2; INTERLEUKIN-3-LIKE ACTIVITY;

D O I：

10.1016/0165-5728(92)90086-Z

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunomodulatory effect of ligands active at the peripheral benzodiazepine receptor (PBR) was examined in human peripheral blood mononuclear cells (PBMC). Ro5-4864, PK11195 and diazepam suppressed phytohemagglutinin (PHA) and concanavalin A (ConA) induced proliferation of PBMC. All three ligands inhibited interleukin-3-like activity (IL-3-LA) secretion, while the production of interleukin-2 (IL-2) was inhibited by Ro5-4864 and diazepam only. The selective central benzodiazepine ligand clonazepam did not affect the cellular immune functions examined. Our results indicate an in-vitro immuno-suppressive activity of peripheral and mixed, but not central type benzodiazepine ligands.

引用

页码：19 / 25

页数：7

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