INFLUENCE OF ELLAGIC ACID ON ANTIOXIDANT DEFENSE SYSTEM AND LIPID-PEROXIDATION IN MICE

被引：50

作者：

MAJID, S ^{[1
]}

KHANDUJA, KL ^{[1
]}

GANDHI, RK ^{[1
]}

KAPUR, S ^{[1
]}

SHARMA, RR ^{[1
]}

机构：

[1] POSTGRAD INST MED EDUC & RES, DEPT BIOPHYS, CHANDIGARH 160012, INDIA

来源：

BIOCHEMICAL PHARMACOLOGY | 1991年 / 42卷 / 07期

关键词：

D O I：

10.1016/0006-2952(91)90457-G

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Addition of ellagic acid (EA) to liver microsomes of mice resulted in a steady increase in inhibition of NADPH-dependent lipid peroxidation up to 2 mM concentration. The maximum of 70% inhibition of ascorbate-dependent lipid peroxidation was achieved at 1 mM concentration of EA. Feeding of EA significantly increased the levels of reduced glutathione and glutathione reductase in liver and lungs of male and female mice. However, there were no changes in the activities of catalase and superoxide dismutase. On the other hand, microsomes from liver and lungs of EA fed animals showed significantly suppressed NADPH- and ascorbate-dependent lipid peroxidation.

引用

页码：1441 / 1445

页数：5

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