EXCEPTIONALLY HIGH INVITRO ANTITUMOR-ACTIVITY OF SUBSTITUTED TRIPHENYLTIN BENZOATES INCLUDING SALICYLATES AGAINST A HUMAN MAMMARY-TUMOR, MCF-7, AND A COLON-CARCINOMA, WIDR

被引：31

作者：

GIELEN, M

WILLEM, R

BIESEMANS, M

BOUALAM, M

ELKHLOUFI, A

DEVOS, D

机构：

[1] FREE UNIV BRUSSELS,CTR HIGH RESOLUT NMR,B-1050 BRUSSELS,BELGIUM

[2] UNIV TETOUAN,FAC SCI,TETOUAN,MOROCCO

[3] PHARMACHEM BV,DEPT MED,HAARLEM,NETHERLANDS

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 1992年 / 6卷 / 03期

关键词：

TRIPHENYLTIN; BENZOATES; ANTITUMOR; MOSSBAUER; NMR;

D O I：

10.1002/aoc.590060307

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Nine new substituted triphenyltin benzoates of the type Ar3Sn-OOC-C6H2XYZ [X = Y = H, Z = 2-OCH3 and 4-F; X = H, Y = 3-F, Z = 5-F; X = H, Y = 2-OH, Z = 5-Cl, 5-NH2, 5-OCH3 and 5-SO3H; X = 2-OH, Y = 3-CH(CH3)2 and Z = 5-CH(CH3)2] were prepared and possess considerable in vitro antitumor activity against two human tumor cell lines (MCF-7, a mammary tumor, and WiDr, a colon carcinoma) comparable with that of mitomycin C.

引用

页码：287 / 291

页数：5