RISK OF SUBSEQUENT BASAL-CELL CARCINOMA AND SQUAMOUS-CELL CARCINOMA OF THE SKIN AMONG PATIENTS WITH PRIOR SKIN-CANCER

被引:237
作者
KARAGAS, MR
STUKEL, TA
GREENBERG, ER
BARON, JA
MOTT, LA
STERN, RS
机构
[1] DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,NORRIS COTTON CANC CTR,HANOVER,NH 03756
[2] HARVARD UNIV,BETH ISRAEL HOSP,BOSTON,MA 02215
[3] DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT MED,HANOVER,NH 03756
来源
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 1992年 / 267卷 / 24期
关键词
D O I
10.1001/jama.267.24.3305
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective.-The primary aims of this study were to assess risk of subsequent basal and squamous cell skin cancer among patients with a prior history of these tumors and to examine these risks in relation to patient characteristics and life-style factors. Design.-Follow-up of participants in a randomized trial of betacarotene as a possible skin cancer preventive agent. Setting.-Clinical centers in Los Angeles, Calif, San Francisco, Calif, Minneapolis, Minn, and Hanover, NH. Participants.-Patients (n=1805) who were diagnosed as having a basal or squamous cell skin cancer between January 1980 and February 1986 and were free of skin cancer at study entry. Main Outcome Measure.-Time from study entry to first new occurrence of basal and squamous cell skin cancer. Results.-The estimated risk of developing one or more new skin cancers was 35% at 3 years and 50% at 5 years. New skin cancers tended to be of the same cell type as the previous skin cancers. For both basal and squamous cell skin cancer, risk was higher among patients who were male, were over the age of 60 years, had more prior skin cancers, had severe actinic skin damage, or who burned easily with sun exposure. Compared with those who had never smoked, the rate of subsequent squamous cell skin cancer was higher among current smokers (rate ratio, 2.01; 95% confidence interval, 1.21 to 3.34) and former smokers (rate ratio, 1.62; 95% confidence interval, 1.07 to 2.47) and increased with both duration and amount smoked. There was no clear relationship between smoking and basal cell skin cancer; the rate appeared lower among heavy smokers but was unrelated to duration of smoking. Conclusions.-Persons with a prior nonmelanoma skin cancer had a substantial 5-year risk of developing another tumor of the same histologic type. Number of previous skin.cancers, solar damage, and skin sensitivity to sun exposure were particularly related to this risk. The increased risk of squamous cell skin cancer associated with cigarette smoking merits further study.
引用
收藏
页码:3305 / 3310
页数:6
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