THE ARGOS GENE ENCODES A DIFFUSIBLE FACTOR THAT REGULATES CELL FATE DECISIONS IN THE DROSOPHILA EYE

被引：219

作者：

FREEMAN, M ^{[1
]}

KLAMBT, C ^{[1
]}

GOODMAN, CS ^{[1
]}

RUBIN, GM ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY, DEPT MOLEC & CELL BIOL, BERKELEY, CA 94720 USA

来源：

CELL | 1992年 / 69卷 / 06期

关键词：

D O I：

10.1016/0092-8674(92)90615-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The argos gene encodes a protein that is required for viability and that regulates the determination of cells in the Drosophila eye. A developmental analysis of argos mutant eyes indicates that the mystery cells, which are usually nonneuronal, are transformed into extra photoreceptors, and that supernumerary cone cells and pigment cells are also recruited. Clonal analysis indicates that argos acts nonautonomously and can diffuse over the range of several cell diameters. Conceptual translation of the argos gene suggests that it encodes a secreted protein.

引用

页码：963 / 975

页数：13

共 59 条

[1] BASIC LOCAL ALIGNMENT SEARCH TOOL
ALTSCHUL, SF
GISH, W
MILLER, W
MYERS, EW
LIPMAN, DJ
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (03) : 403 - 410
[2] ARMAYA E, 1991, CELL, V66, P257
[3] CHOOSING A CELL FATE - A VIEW FROM THE NOTCH LOCUS
ARTAVANISTSAKONAS, S
SIMPSON, P
[J]. TRENDS IN GENETICS, 1991, 7 (11-12) : 403 - 408
[4] NOVEL ACTIVIN RECEPTORS - DISTINCT GENES AND ALTERNATIVE MESSENGER-RNA SPLICING GENERATE A REPERTOIRE OF SERINE THREONINE KINASE RECEPTORS
ATTISANO, L
WRANA, JL
CHEIFETZ, S
MASSAGUE, J
[J]. CELL, 1992, 68 (01) : 97 - 108
[5] SPACING DIFFERENTIATION IN THE DEVELOPING DROSOPHILA EYE - A FIBRINOGEN-RELATED LATERAL INHIBITOR ENCODED BY SCABROUS
BAKER, NE
MLODZIK, M
RUBIN, GM
[J]. SCIENCE, 1990, 250 (4986) : 1370 - 1377
[6] MOLECULAR-CLONING OF SEQUENCES FROM WINGLESS, A SEGMENT POLARITY GENE IN DROSOPHILA - THE SPATIAL-DISTRIBUTION OF A TRANSCRIPT IN EMBRYOS
BAKER, NE
[J]. EMBO JOURNAL, 1987, 6 (06) : 1765 - 1773
[7] EFFECT ON EYE DEVELOPMENT OF DOMINANT MUTATIONS IN DROSOPHILA HOMOLOG OF THE EGF RECEPTOR
BAKER, NE
RUBIN, GM
[J]. NATURE, 1989, 340 (6229) : 150 - 153
[8] LIGAND-INDEPENDENT ACTIVATION OF THE SEVENLESS RECEPTOR TYROSINE KINASE CHANGES THE FATE OF CELLS IN THE DEVELOPING DROSOPHILA EYE
BASLER, K
CHRISTEN, B
HAFEN, E
[J]. CELL, 1991, 64 (06) : 1069 - 1081
[9] IDENTIFICATION AND CHARACTERIZATION OF A NEURON-SPECIFIC NUCLEAR ANTIGEN IN DROSOPHILA
BIER, E
ACKERMAN, L
BARBEL, S
JAN, L
JAN, YN
[J]. SCIENCE, 1988, 240 (4854) : 913 - 916
[10] NOTCH IS REQUIRED FOR SUCCESSIVE CELL DECISIONS IN THE DEVELOPING DROSOPHILA RETINA
CAGAN, RL
READY, DF
[J]. GENES & DEVELOPMENT, 1989, 3 (08) : 1099 - 1112

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