ENDOTHELIUM-DEPENDENT VASODILATOR EFFECTS OF THE EXTRACT FROM SALVIAE-MILTIORRHIZAE-RADIX - A STUDY ON THE IDENTIFICATION OF LITHOSPERMIC ACID-B IN THE EXTRACTS

被引：77

作者：

KAMATA, K ^{[1
]}

IIZUKA, T ^{[1
]}

NAGAI, M ^{[1
]}

KASUYA, Y ^{[1
]}

机构：

[1] HOSHI UNIV,SCH PHARMACEUT SCI,DEPT PHARMACOGNOSY,SHINAGAWA KU,TOKYO 142,JAPAN

来源：

GENERAL PHARMACOLOGY | 1993年 / 24卷 / 04期

关键词：

D O I：

10.1016/0306-3623(93)90176-X

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

1. The aqueous extract of Salviae Miltiorrhizae radix (Chinese crude drug named ''dan-shen'') relaxed the noradrenaline-precontracted aorta with endothelium. 2. Vasodilation by the extract disappeared in aorta without endothelium, and was inhibited by pretreatment with 10(-4) M N(G)-monomethyl-L-arginine (L-NMMA) or 10(-5) M methylene blue. 3. The inhibition of the extract-induced vasodilation by L-NMMA was reversed by L-arginine (3 x 10(-4) M). 4. The component of the extract was analyzed by chromatography, fast atom bombardment mass spectroscopy (FAB-MS) and H-1-NMR. 5. An active component of the extract, which showed endothelium-dependent vasodilation, was found to be identical with lithospermic acid B.

引用

页码：977 / 981

页数：5

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