BIOTRANSFORMATIONS OF ALPHA,BETA-EPOXYALCOHOLS CATALYZED BY EPOXIDE HYDROLASES

被引：1

作者：

DAIBOUN, T

ELALAOUI, MA

THALERDAO, H

CHAVIS, C

MAURY, G

机构：

[1] UNIV MONTPELLIER 2, DEPT CHIM ORGAN FINE, F-34095 MONTPELLIER 5, FRANCE

[2] INSERM, U58, F-34090 MONTPELLIER, FRANCE

来源：

BIOCATALYSIS | 1993年 / 7卷 / 04期

关键词：

MICROSOMAL AND CYTOSOLIC EPOXIDE HYDROLASES; ALPHA; BETA-EPOXYALCOHOLS; 1,2,3-TRIOLS; KINETIC RESOLUTIONS;

D O I：

10.3109/10242429308992096

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microsomal and cytosolic fractions of mammalian livers were screened for their capacity to resolve racemic mixtures of trans-2,3-epoxy-1-alkanols. The epoxide hydrolase activities showed some specificity for the 2S,3S enantiomers which were attacked at the proximate carbon atom. The best resolutions were observed with guinea pig liver microsomal enzymes.

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页码：227 / 236

页数：10

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