SYNTHESIS AND RADIOIODINATION OF A NIDO-1,2-CARBORANYL DERIVATIVE OF 2-NITROIMIDAZOLE

被引：26

作者：

WILBUR, DS ^{[1
]}

HAMLIN, DK ^{[1
]}

LIVESEY, JC ^{[1
]}

SRIVASTAVA, RR ^{[1
]}

LARAMORE, GE ^{[1
]}

GRIFFIN, TW ^{[1
]}

机构：

[1] UNIV WASHINGTON,DEPT RADIAT ONCOL,SEATTLE,WA 98195

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1994年 / 21卷 / 04期

关键词：

D O I：

10.1016/0969-8051(94)90025-6

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The synthesis of a nido-carboranyl congener of misonidazole, 1-(3'-nido-carboranyl-2'-hydroxy)propyl-2-nitroimidazole, has been carried out. Alternative methods of preparations were conducted to optimize the chemical yield, with a five step synthesis giving an overall yield (from 1,2-carborane) of 36%. A diastereomeric pair of nido-carboranyl compounds was obtained. The diastereomeric nido-carboranyl misonidazole congeners were (radio)iodinated to yield (> 90%) a mixture of diastereomeric compounds in which the iodine had bonded to a boron atom on the nido-carborane moiety. These compounds will be investigated for their application to boron neutron capture therapy (BNCT) and hypoxia imaging of cancer.

引用

页码：601 / 611

页数：11

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