FUNGAL METABOLITES .14. NOVEL POTENT IMMUNOSUPPRESSANTS, MYCESTERICINS, PRODUCED BY MYCELIA-STERILIA

被引：77

作者：

SASAKI, S

HASHIMOTO, R

KIUCHI, M

INOUE, K

IKUMOTO, T

HIROSE, R

CHIBA, K

HOSHINO, Y

OKUMOTO, T

FUJITA, T

机构：

[1] KYOTO UNIV, FAC PHARMACEUT SCI, SAKYO KU, KYOTO 60601, JAPAN

[2] YOSHITOMI PHARMACEUT IND LTD, TOKYO RES LABS, SAITAMA 358, JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 04期

关键词：

D O I：

10.7164/antibiotics.47.420

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mycestericins A, B, C, D and E were isolated from the culture broth of Mycelia sterilia ATCC 20349 along with thermozymocidin (=myriocin). Their structures were elucidated on the basis of spectroscopic studies and chemical evidence. The acetate of mycestericin C was identical with the acetate of 6,7-dihydromyriocin. Mycestericins suppressed the proliferation of lymphocytes in the mouse allogeneic mixed lymphocyte reaction, with a potency similar to that of myriocin.

引用

页码：420 / 433

页数：14

共 9 条

[1] ISOLATION AND STRUCTURE DETERMINATION OF A NEW ANTIFUNGAL ALPHA-HYDROXYMHTHYL-ALPHA-AMINO ACID
ARAGOZZINI, F
CRAVERI, R
SCOLASTICO, C
RINDONE, B
MANACHINI, PL
[J]. TETRAHEDRON, 1972, 28 (21) : 5493 - +
[2] ELUCIDATION OF STRUCTURE AND STEREOCHEMISTRY OF MYRIOCIN - NOVEL ANTIFUNGAL ANTIBIOTIC
BAGLI, JF
KLUEPFEL, D
STJACQUE.M
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1973, 38 (07) : 1253 - 1260
[3] FUJITA T, 1994, CHEM PHARM BULL, V42, P489, DOI 10.1248/cpb.42.489
[4] FUNGAL METABOLITES .11. A POTENT IMMUNOSUPPRESSIVE ACTIVITY FOUND IN ISARIA-SINCLAIRII METABOLITE
FUJITA, T
INOUE, K
YAMAMOTO, S
IKUMOTO, T
SASAKI, S
TOYAMA, R
CHIBA, K
HOSHINO, Y
OKUMOTO, T
[J]. JOURNAL OF ANTIBIOTICS, 1994, 47 (02) : 208 - 215
[5] FUNGAL METABOLITES .12. POTENT IMMUNOSUPPRESSANT, 14-DEOXOMYRIOCIN, (2S,3R,4R)-(E)-2-AMINO-3,4-DIHYDROXY-2-HYDROXYMETHYLEICOS-6-ENOIC ACID AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF MYRIOCIN DERIVATIVES
FUJITA, T
INOUE, K
YAMAMOTO, S
IKUMOTO, T
SASAKI, S
TOYAMA, R
YONETA, M
CHIBA, K
HOSHINO, Y
OKUMOTO, T
[J]. JOURNAL OF ANTIBIOTICS, 1994, 47 (02) : 216 - 224
[6] FUJITA T, 1990, 17TH IUPAC INT S CHE, P68
[7] GENELLA NC, 1982, J AM CHEM SOC, V104, P3775
[8] MYRIOCIN, A NEW ANTIFUNGAL ANTIBIOTIC FROM MYRIOCOCCUM-ALBOMYCES
KLUEPFEL, D
VEZINA, C
SEHGAL, SN
KUDELSKI, A
CHAREST, MP
BAGLI, J
[J]. JOURNAL OF ANTIBIOTICS, 1972, 25 (02) : 109 - +
[9] 4 FUNGITOXIC C-18 HYDROXY UNSATURATED FATTY-ACIDS FROM STROMATA OF EPICHLOE-TYPHINA
KOSHINO, H
TOGIYA, S
YOSHIHARA, T
SAKAMURA, S
SHIMANUKI, T
SATO, T
TAJIMI, A
[J]. TETRAHEDRON LETTERS, 1987, 28 (01) : 73 - 76

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