NEW CHIRAL AMINOPHOSPHINES AND THEIR USE IN ASYMMETRIC CATALYSIS

被引:97
作者
WIMMER, P
WIDHALM, M
机构
[1] Institut für Organische Chemie, Universität Wien, A-1090 Vienna
关键词
D O I
10.1016/0957-4166(95)00053-R
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Chiral aminophosphines 4, 5 and 8 were synthesized from 1 in 34%, 57% and 42% overall yield, respectively. The new ligands were investigated with respect to their efficiency in the allylic alkylation of 1,3-diphenyl-1-acetoxy-2-propene with sodium malonate, the cross-coupling reaction of phenethylmagnesium chloride with vinyl bromide, and asymmetric hydrogenations of unsatured mono- and dicarbonic acids. The highest asymmetric inductions were observed with 4 (dimethyl 1,3-diphenyl-allyl-propandioate, 96% e.e.) and 5 (N-acetylphenylalanine, 77% e.e.; methylsuccinic acid, 56% e.e., 3-phenyl-1-butene 47% e.e.).
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页码:657 / 660
页数:4
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