C-FOS EXPRESSION AFTER SINGLE AND KINDLED AUDIOGENIC-SEIZURES IN WISTAR RATS

被引：65

作者：

SIMLER, S ^{[1
]}

HIRSCH, E ^{[1
]}

DANOBER, L ^{[1
]}

MOTTE, J ^{[1
]}

VERGNES, M ^{[1
]}

MARESCAUX, C ^{[1
]}

机构：

[1] HOP UNIV STRASBOURG, NEUROL CLIN, INSERM, U398, F-67091 STRASBOURG, FRANCE

来源：

NEUROSCIENCE LETTERS | 1994年 / 175卷 / 1-2期

关键词：

C-FOS; AUDIOGENIC SEIZURE; BRAIN-STEM SEIZURE; KINDLING; AMYGDALA; HIPPOCAMPUS; RAT; EPILEPSY;

D O I：

10.1016/0304-3940(94)91077-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In naive Wistar rats susceptible to sound, a single audiogenic seizure induced the expression of c-fos in the subcortical auditory nuclei whereas the forebrain was almost completely devoid of any labelling. After kindling of audiogenic seizures by 40 daily exposures to sound, the seizure induced a strong c-fos expression in the amygdala, the piriform cortex, the hippocampus and the neocortex. These results confirm: (i) that audiogenic seizures are brain-stem seizures related to dysfunction of auditory pathways, and (ii) that kindling of audiogenic seizures recruits forebrain and limbic structures into the seizure network.

引用

页码：58 / 62

页数：5

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