NEUROTRANSMISSION HARNESSING FUSION MACHINERY AT THE SYNAPSE

被引：152

作者：

SOLLNER, T

ROTHMAN, JE

机构：

[1] Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021

来源：

TRENDS IN NEUROSCIENCES | 1994年 / 17卷 / 08期

关键词：

D O I：

10.1016/0166-2236(94)90178-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurotransmission requires the docking of synaptic vesicles to the presynaptic plasma membrane, and their signal-dependent fusion. These processes use a general 'machinery' operating at several intracellular vesicular transport steps and, in addition, use a set of unique components that characterizes this specific form of regulated secretion. This review summarizes recent progress that has significantly increased our understanding, of how intracellular transport vesicles dock and fuse with their target membrane, both in the synapse and elsewhere.

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页码：344 / 348

页数：5

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