ULTRASTRUCTURAL ANALYSIS OF THE CELLULAR-RESPONSE TO SCHISTOSOMA-MANSONI .2. INFLAMMATORY RESPONSES IN RODENT SKIN

被引:26
作者
BENTLEY, AG
CARLISLE, AS
PHILLIPS, SM
机构
关键词
D O I
10.4269/ajtmh.1981.30.815
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
A significant proportion of S. mansoni schistosomula die soon after penetration of mammalian host skin. This study was conducted to further define the host cellular response which occurs in the skin and which may contribute to early schistosomulum death in the resistant CDF rat and the more susceptible BALB/c mouse. In primary abdominal skin exposures of both hosts the initial 6-h response is marked edema and epidermal cell disruption in the schistosomulum penetration tracts accompanied by migration of neutrophils to surround the parasites and into damaged areas of the epidermis and dermis. Challenge exposures in previously infected hosts result in more intense exudative inflammation than is observed in initial exposures with the additional infiltration of eosinophils into the dermis and epidermis. Mast cells are numerous and are occasionally observed degranulating. By 24 h following either initial or challenge exposures the infiltration of granulocytes is more intense. Focal areas of neutrophils, eosinophils and necrotic cells are frequent in the epidermis. Postcapillary venules contain large numbers of granulocytes. The vascular endothelium is frequently vacuolated and occasionally exhibits focal degeneration. Rat hosts show responses which are qualitatively similar to those in mouse hosts but quantitatively more intense. Smaller numbers of eosinophils were observed in the immune mouse at 24 h than have been reported in previous studies. This may be attributable to differences in strain, in the time course of response in abdominal as compared with ear skin, or in the levels of immunity in the animals used.
引用
收藏
页码:815 / 824
页数:10
相关论文
共 31 条
[1]   THE MAST CELL - ITS STRUCTURE AND FUNCTION [J].
BENDITT, EP ;
LAGUNOFF, D .
PROGRESS IN ALLERGY, 1964, 8 :195-223
[2]   MIGRATION OF SCHISTOSOMA-MANSONI THROUGH MOUSE TISSUE - ULTRASTRUCTURE OF HOST TISSUE AND INTEGUMENT OF MIGRATING LARVA FOLLOWING CERCARIAL PENETRATION [J].
BRUCE, JI ;
PEZZLO, F ;
MCCARTY, JE ;
YAJIMA, Y .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1970, 19 (06) :959-+
[3]   ANTIBODY-DEPENDENT EOSINOPHIL-MEDIATED DAMAGE TO CR-51-LABELED SCHISTOSOMULA OF SCHISTOSOMA-MANSONI - DAMAGE BY PURIFIED EOSINOPHILS [J].
BUTTERWORTH, AE ;
DAVID, JR ;
FRANKS, D ;
MAHMOUD, AAF ;
DAVID, PH ;
STURROCK, RF ;
HOUBA, V .
JOURNAL OF EXPERIMENTAL MEDICINE, 1977, 145 (01) :136-150
[4]   IGE AND CELLS IN SCHISTOSOMIASIS [J].
CAPRON, A ;
DESSAINT, JP ;
JOSEPH, M ;
TORPIER, G ;
CAPRON, M ;
ROUSSEAUX, R ;
SANTORO, F ;
BAZIN, H .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1977, 26 (06) :39-47
[5]   PARTIAL AND COMPLETE DETACHMENT OF NEUTROPHILS AND EOSINOPHILS FROM SCHISTOSOMULA - EVIDENCE FOR THE ESTABLISHMENT OF CONTINUITY BETWEEN A FUSED AND NORMAL PARASITE MEMBRANE [J].
CAULFIELD, JP ;
KORMAN, G ;
BUTTERWORTH, AE ;
HOGAN, M ;
DAVID, JR .
JOURNAL OF CELL BIOLOGY, 1980, 86 (01) :64-76
[6]   THE ADHERENCE OF HUMAN-NEUTROPHILS AND EOSINOPHILS TO SCHISTOSOMULA - EVIDENCE FOR MEMBRANE-FUSION BETWEEN CELLS AND PARASITES [J].
CAULFIELD, JP ;
KORMAN, G ;
BUTTERWORTH, AE ;
HOGAN, M ;
DAVID, JR .
JOURNAL OF CELL BIOLOGY, 1980, 86 (01) :46-63
[7]   DEATH OF SCHISTOSOME CERCARIAE DURING PENETRATION OF SKIN .2. PENETRATION OF MAMMALIAN SKIN BY SCHISTOSOMA MANOSONI [J].
CLEGG, JA ;
SMITHERS, SR .
PARASITOLOGY, 1968, 58 :111-&
[8]   IMMUNOPATHOLOGY OF DERMAL REACTIONS INDUCED BY SCHISTOSOMA-MANSONI CERCARIAE AND CERCARIAL EXTRACT [J].
COLLEY, DG ;
COELHO, RB ;
MAGALHAE.A .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1972, 21 (05) :558-+
[9]   COMBINED INVITRO EFFECTS OF RAT ANTIBODY AND NEUTROPHILIC LEUKOCYTES ON SCHISTOSOMULA OF SCHISTOSOMA-MANSONI [J].
DEAN, DA ;
WISTAR, R ;
MURRELL, KD .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1974, 23 (03) :420-428
[10]  
DEAN DA, 1976, FED PROC, V35, P228