LEUKOTRIENES AND RELATED EICOSANOIDS ARE PRODUCED BY FROG LEUKOCYTES

被引：19

作者：

GREEN, FA ^{[1
]}

HERMAN, CA ^{[1
]}

HERMAN, RP ^{[1
]}

CLAESSON, HE ^{[1
]}

HAMBERG, M ^{[1
]}

机构：

[1] KAROLINSKA INST, DEPT PHYSIOL CHEM, S-10401 STOCKHOLM 60, SWEDEN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1987年 / 142卷 / 02期

关键词：

D O I：

10.1016/0006-291X(87)90274-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The metabolites of inflammatory cells produced by massive infection of the peritoneal cavity of two related European species of frogs, Rana temporaria and Rana arvalis were examined for lipoxygenase-generated products of exogenous arachidonic acid. Cells of Rana temporaria produced large amounts of 5-hydroxyeicosatetraenoic acid and leukotriene B4. Cells from Rana arvalis produced only 15-hydroxyeicosatetraenoic acid. This is the first unequivocal demonstration of such enzyme activity in lower vertebrates. There was a trend towards increased mortality in the species without evidence of 5-lipoxygenase activity.

引用

页码：309 / 314

页数：6

共 16 条

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