ASSESSMENT OF ANTIGENIC DETERMINANTS FOR THE HUMAN T-CELL RESPONSE AGAINST MYELIN BASIC-PROTEIN USING OVERLAPPING SYNTHETIC PEPTIDES

被引:20
作者
BURNS, J
LITTLEFIELD, K
GOMEZ, C
KUMAR, V
机构
[1] UNIV UTAH,DEPT NEUROL,SALT LAKE CITY,UT 84132
[2] CALTECH,ARTHUR AMOS NOYES LAB CHEM PHYS,DIV BIOL,PASADENA,CA 91125
关键词
MYELIN BASIC PROTEIN; AUTOIMMUNITY; MULTIPLE SCLEROSIS;
D O I
10.1016/0165-5728(91)90016-Z
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Immunization of experimental animals with myelin basic protein (MBP) or with specific MBP encephalitogenic determinants induces an autoimmune central nervous system (CNS) disease, experimental allergic encephalomyelitis, often studied as a model for human demyelinating disorders. This study examines the antigenic determinants of MBP recognized by human T cells using overlapping, synthetic peptides and T cell lines and clones isolated from four HLA-typed, neurologically normal subjects. T cell lines and clones isolated from individual subjects recognized at least one and as many as five distinct T cell determinants. In some instances the peptides recognized included determinants previously shown to induce experimental allergic encephalomyelitis (EAE) in experimental animals. In this group of four subjects, some determinants of MBP, including residues 5-25, 35-47, 65-75, and 81-100, were recognized by T cells derived from more than one individual suggesting that these regions may be particularly immunogenic for humans.
引用
收藏
页码:105 / 113
页数:9
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