SEVERE NEONATAL PROTEIN-C DEFICIENCY - PREVALENCE AND THROMBOTIC RISK

被引:75
作者
MANCOJOHNSON, MJ [1 ]
ABSHIRE, TC [1 ]
JACOBSON, LJ [1 ]
MARLAR, RA [1 ]
机构
[1] USAF, MED CTR, DEPT PEDIAT, KEESLER AFB, MS 39534 USA
关键词
D O I
10.1016/S0022-3476(05)80305-1
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Severe deficiencies of protein C, a pivotal coagulation-regulatory protein, have been reported in neonates as an apparently transient condition. In this prospective study, cord blood was collected at 193 deliveries and assays of protein C were correlated with clinical status, other coagulation results, and outcome. Protein C levels of < 0.l unit/ml were found most frequently in preterm infants with respiratory distress, infants of diabetic mothers, and infants of twin gestations. Levels of protein C correlated with levels of factor VIII activity but did not correlate with markers of consumptive coagulopathy. A protein C level < 0.l unit/ml was significantly correlated with the subsequent onset of thrombosis, even when the effects of gestational age and birth weight were excluded. Low cord blood levels of protein C may reflect delayed maturation or increased turnover in certain infants and appear to convey an independent risk of thrombosis, but the critical concentration of protein C necessary to maintain neonatal hemostasis is not known.
引用
收藏
页码:793 / 798
页数:6
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