IDENTIFICATION OF SUSCEPTIBILITY LOCI FOR TYPE-1 (INSULIN-DEPENDENT) DIABETES BY TRANSRACIAL GENE-MAPPING

被引：54

作者：

JENKINS, D

MIJOVIC, C

FLETCHER, J

JACOBS, KH

BRADWELL, AR

BARNETT, AH

机构：

[1] E BIRMINGHAM DIST GEN HOSP, DEPT MED, BORDESLEY GREEN E, BIRMINGHAM B9 5ST, W MIDLANDS, ENGLAND

[2] E BIRMINGHAM DIST GEN HOSP, DEPT IMMUNOL, BIRMINGHAM B9 5ST, W MIDLANDS, ENGLAND

[3] UNIV BIRMINGHAM, DEPT MED, BIRMINGHAM B15 2TT, W MIDLANDS, ENGLAND

[4] UNIV BIRMINGHAM, DEPT IMMUNOL, BIRMINGHAM B15 2TT, W MIDLANDS, ENGLAND

来源：

DIABETOLOGIA | 1990年 / 33卷 / 07期

基金：

英国惠康基金;

关键词：

DNA; gene mapping; HLA; MHC; trans-racial studies; Type; 1; diabetes;

D O I：

10.1007/BF00404086

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A major component of inherited susceptibility to Type 1 (insulin-dependent) diabetes mellitus has been mapped to the major histocompatibility complex. Certain gene alleles in this region determine susceptibility and resistance to the disease. Mapping of susceptibility is hindered by the limitations of conventional tissue typing techniques, and by strong linkage disequilibrium within this part of the genome. Recombinant DNA technology and trans-racial studies have been used to allow finer mapping of genetic predisposition to Type 1 diabetes. These techniques have localised alleles encoding susceptibility and resistance to the DQ region. Other alleles determining disease susceptibility remain poorly localised. © 1990 Springer-Verlag.

引用

页码：387 / 395

页数：9

共 73 条

[1] HLA-DQ SYSTEM AND INSULIN-DEPENDENT DIABETES-MELLITUS IN JAPANESE - DOES IT CONTRIBUTE TO THE DEVELOPMENT OF IDDM AS IT DOES IN CAUCASIANS [J].