ROUTINE SCREENING METHOD FOR THE MAJOR METABOLITE OF METHYL PHENIDATE IN THE URINE OF GREYHOUNDS

被引：1

作者：

LEWIS, JH

机构：

[1] Department of Pharmacology, University of Sydney

来源：

FORENSIC SCIENCE INTERNATIONAL | 1979年 / 14卷 / 03期

关键词：

D O I：

10.1016/0379-0738(79)90141-5

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

A qualitative urine screening procedure for the determination of the major urinary metabolite of methyl phenidate, α-phenyl-2-piperidine acetic acid (ritalinic acid), has been devised. The method involves a salting-out extraction, conversion of the metabolite to the parent drug using methanol-hydrogen chloride, and simultaneous two-column gaschromatographic detection. Final confirmation of the presence of the drug is by two-system thin-layer chromatography. The method is suitable for the detection of illicitly administered methyl phenidate in greyhounds. © 1979.

引用

页码：221 / 227

页数：7

共 7 条

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[3] Wells, Hammond, Rodgerson, Gas-liquid chromatographic procedure for measurement of methyl phenidate hydrochloride and its metabolite, ritalinic acid, in urine, Clin. Chem., 20-24, pp. 440-443, (1974)
[4] Faraj, Israili, Perel, Jenkins, Holtzman, Cucinell, Dayton, Metabolism and disposition of methyl phenidate-<sup>14</sup>C: studies in man and animals, J. Pharm. Exp. Ther., 191, pp. 535-547, (1974)
[5] Milberg, Rinehart, Sprague, Sleator, A reproducible gas chromatographic mass spectrometric assay for low levels of methyl phenidate and ritalinic acid in blood and urine, Biomed. Mass Spectrom., 2, pp. 2-8, (1975)
[6] Delbeke, Debackere, Isolation and detection of methyl phenidate, phacetoperane and some other sympathomimetic central nervous stimulants with special reference to doping, J. Chromatogr., 106, pp. 412-417, (1975)
[7] Kazyak, Permisohn, Retention indices for compound identification by gas chromatography, J. Forensic Sci., 15, pp. 346-356, (1970)

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