PROLONGED FECAL EXCRETION OF POLIOVIRUS IN A NURSE WITH COMMON VARIABLE HYPOGAMMAGLOBULINEMIA

被引：26

作者：

MISBAH, SA

LAWRENCE, PA

KURTZ, JB

CHAPEL, HM

机构：

[1] RADCLIFFE INFIRM,DEPT OCCUPAT HLTH,OXFORD OX2 6HE,ENGLAND

[2] JOHN RADCLIFFE HOSP,DEPT VIROL,OXFORD OX3 9DU,ENGLAND

来源：

POSTGRADUATE MEDICAL JOURNAL | 1991年 / 67卷 / 785期

关键词：

D O I：

10.1136/pgmj.67.785.301

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A nurse with common variable hypogammaglobulinaemia was found to excrete a non-vaccine strain type II poliovirus for almost a year following a bout of gastroenteritis. Attempts were made to halt intestinal carriage of the virus in view of the possible risk of spread to immunocompromised patients and the risk of paralytic poliomyelitis to the patient himself. Three doses of killed Salk vaccine failed to stimulate salivary anti-polio antibodies. Excretion of the virus ceased spontaneously just before oral immunoglobulin containing high titres of antibodies to polio virus was used to halt virus excretion.

引用

页码：301 / 303

页数：3

共 9 条

[1]

CHANG TW, 1966, PEDIATRICS, V37, P630

[2] INCREASED NEUROVIRULENCE ASSOCIATED WITH A SINGLE NUCLEOTIDE CHANGE IN A NONCODING REGION OF THE SABIN TYPE-3 POLIOVACCINE GENOME [J].