ANTIGENIC VARIATION IN BORRELIA

被引：19

作者：

SAINTGIRONS, I

BARBOUR, AG

机构：

[1] UNIV TEXAS,HLTH SCI CTR,DEPT MICROBIOL,SAN ANTONIO,TX 78284

[2] UNIV TEXAS,HLTH SCI CTR,DEPT MED,SAN ANTONIO,TX 78284

来源：

RESEARCH IN MICROBIOLOGY | 1991年 / 142卷 / 06期

关键词：

PLASMID; TRANSPOSITION; ANTIGENICITY; BORRELIA; VMP; ANTIGENIC VARIATION; BIOLOGY; PATHOLOGY;

D O I：

10.1016/0923-2508(91)90085-O

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antigenic variation was demonstrated for the agent of relapsing fever, Borrelia hermsii. The phenomenon is correlated with changes in major surface proteins called Vmp. The genes encoding these antigens are located on linear plasmids. Expression occurs by transposition of genes encoding Vmp to a telomeric expression site located on another linear plasmid. Activation of a vmp gene occurs by placing it downstream from a promoter. Resemblance to the antigenic variation of trypanosomes is discussed.

引用

页码：711 / 717

页数：7

共 31 条

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