CARDIAC METABOLISM IN PATIENTS WITH DILATED AND HYPERTROPHIC CARDIOMYOPATHY - ASSESSMENT WITH PROTON-DECOUPLED P-31 MR SPECTROSCOPY

被引：96

作者：

DEROOS, A

DOORNBOS, J

LUYTEN, PR

OOSTERWAAL, LJMP

VANDERWALL, EE

DENHOLLANDER, JA

机构：

[1] Department of Diagnostic Radiology, University Hospital Leiden, Leiden, 2333 AA

[2] MR Physics Department, Philips Medical Systems, Best

[3] Department of Cardiology, University Hospital Leiden, Leiden, 2333 AA, Bldg 1-C2-S

[4] Inter University, Cardiology Institute, Utrecht

来源：

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1992年 / 2卷 / 06期

关键词：

HEART; DISEASES; MAGNETIC RESONANCE (MR); SPECTROSCOPY; MYOCARDIUM; MR; PHOSPHORUS STUDIES;

D O I：

10.1002/jmri.1880020616

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Proton-decoupled phosphorus-31 heart spectroscopy was performed in healthy subjects (n = 9) and patients with dilated cardiomyopathy (DCM, n = 9) or hypertrophic cardiomyopathy (HCM, n = 8). The phosphocreatine (PCr)-to-adenosine triphosphate ratio (+/- one standard deviation) after correction for blood contribution and partial saturation was significantly lower in HCM patients relative to the control subjects (1.32 +/- 0.29 vs 1.65 +/- 0.26, P < .05) but not in DCM patients (1.52 +/- 0.58 vs 1.65 +/- 0.26). The inorganic phosphate (Pi) peak was resolved only in patients with the highest spectral quality. Myocardial pH was lower in HCM patients (n = 6) relative to control subjects (n = 4) (7.07 +/- 0.07 vs 7.15 +/- 0.03, P < .05). The Pi/PCr ratio was higher in DCM (n = 3) and HCM (n = 6) patients relative to control subjects (n = 4) (0.29 +/- 0.06 and 0.20 +/- 0.04, respectively, vs 0. 14 +/- 0.06; P < .05). Elevated phosphodiester signal in DCM patients correlated with 2,3-diphosphoglycerate signal (r = .94), reflecting blood pool contamination. P-31 spectroscopy enabled detection of abnormalities in cardiac metabolism and determination of pH in patients with HCM and DCM.

引用

页码：711 / 719

页数：9

共 32 条

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