FRACTIONATED-IRRADIATION AND EARLY CHANGES IN NORADRENALINE INDUCED POTASSIUM EFFLUX (86RB+) IN RAT PAROTID-GLAND

被引：10

作者：

FRANZEN, L

SUNDSTROM, S

KARLSSON, M

GUSTAFSSON, H

LITTBRAND, B

HENRIKSSON, R

机构：

[1] UMEA UNIV HOSP, DEPT ONCOL, S-90185 UMEA, SWEDEN

[2] UMEA UNIV HOSP, DEPT HISTOL & CELL BIOL, S-90185 UMEA, SWEDEN

[3] UMEA UNIV HOSP, DEPT RADIAT PHYS, S-90185 UMEA, SWEDEN

[4] UMEA UNIV HOSP, DEPT OTOLARYNGOL, S-90185 UMEA, SWEDEN

来源：

ACTA ONCOLOGICA | 1992年 / 31卷 / 03期

关键词：

D O I：

10.3109/02841869209108186

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effects of fractionated irradiation on the electrolyte fluid secretion from rat parotid gland were studied. Secretion was measured as noradrenaline stimulated potassium efflux in vitro with Rb-86+ as tracer for potassium. The irradiation was delivered either as a five-day schedule (total dose 20, 25, 30, 35, 40, 45 Gy) or a two-day schedule (total dose 24, 32 Gy). The noradrenaline stimulated efflux was decreased in comparison with contralateral controls 10 days after the last irradiation. The effect was dose-dependent. Based on the data available, alpha/beta ratio of the used system was calculated to about 20 Gy, which corresponds to other results regarding early radiation effects.

引用

页码：359 / 364

页数：6

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